Which factor in a client’s history poses the greatest risk for cervical cancer?

The factor that poses the greatest risk for cervical cancer is having multiple sexual partners. This is primarily because a higher number of sexual partners increases the likelihood of exposure to human papillomavirus (HPV), which is a significant contributing factor in the development of cervical cancer. HPV is a sexually transmitted virus, and certain high-risk types of HPV are directly associated with the changes in cervical cells that can lead to cancer over time.

While other factors listed may contribute to the overall risk for cervical cancer, they do not have the same direct link as multiple sexual partners and HPV exposure. Nulliparity, early menarche, and hormone-replacement therapy are not as strongly connected to the progression of cervical cancer as the history of multiple sexual partners, particularly in relation to HPV infection. Therefore, recognizing the impact of sexual behavior on health outcomes is crucial in understanding and reducing the risk for cervical cancer.